In the summer of 2000, was released Eddie Murphy's movie Nutty Professor II: The Klumps, with Eddie Murphy featuring as six characters.
In 2001, the success seemed to caught Eddie Murphy again with two big box office hits: Dr Doolittle 2 and Shrek, in which Eddie Murphy lend his voice to the Donkey character.
In 2002, Eddie Murphy played Officer Trey Sellers in Showtime, Pluto Nash in The Andventures of Pluto Nash and Kelly Robinson in I Spy.
In 2003 Eddie Murphy was cast in the family-oriented comedy Daddy Day Care and in 2004, the comedian lend his voice again to the character of Donkey in Shrek 2.
In 2006, Eddie Murphy playes "James Thunder Early" in the adapation of the musical Dreamgirls, directed by Bill Condon and released by DreamWorks Pictures and Paramount Pictures.
In 2007, Eddie Murphy played several characters in the comedy Norbit, being Norbit Rice/Rasputia Latimore-Rice/Mr. Wong and in the same year, Eddie Murphy's voice gave life again to the Donkey in Shrek, the third.
In July 2008, was released by 20th Century Fox, Eddie Murphy's movie "Meet Dave", an american family commedy, directed by Brian Robbinson.
In 2009 is programmed to be released the comedy fantasy Imagine That, starring Eddie Murphy and also the movie A Thousand Words.
For 2010, Eddie Murphy has three more projects: continues to be the voice of the character Donkey in Shrek Goes Fourth, continues the work as Axwl Foley in Beverly Hills Cop IV and a new movie: The Incredible Shrinking Man.